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KMID : 0923620150150050260
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Immune Network
2015 Volume.15 No. 5 p.260 ~ p.267
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Engagement of CD99 Reduces AP-1 Activity by Inducing BATF in the Human Multiple Myeloma Cell Line RPMI8226
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:Gil Min-Chan
:Park Hyo-Kyung/:Lee A-Neum/:Park Seo-Jeong/:Lee Hyang-sin/:Lee Hyun-ji/:Park Chan-Sik/:Park Young-Soo/:Kim Kyung-Eun/:Lee Kyung-Jin/:Yoon Dok-Hyun/:Chung Yoo-Sam
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Abstract
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CD99 signaling is crucial to a diverse range of biological functions including survival and proliferation. CD99 engagement is reported to augment activator protein-1 (AP-1) activity through mitogen-activated protein (MAP) kinase pathways in a T-lymphoblastic lymphoma cell line Jurkat and in breast cancer cell lines. In this study, we report that CD99 differentially regulated AP-1 activity in the human myeloma cell line RPMI8226. CD99 was highly expressed and the CD99 engagement led to activation of the MAP kinases, but suppressed AP-1 activity by inducing the expression of basic leucine zipper transcription factor, ATF-like (BATF), a negative regulator of AP-1 in RPMI8226 cells. By contrast, engagement of CD99 enhanced AP-1 activity and did not change the BATF expression in Jurkat cells. CD99 engagement reduced the proliferation of RPMI8226 cells and expression of cyclin 1 and 3. Overall, these results suggest novel CD99 functions in RPMI8226 cells.
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KEYWORD
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CD99, BATF, AP-1, Proliferation, MAP kinase
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